Intoxication by tremorgenic mycotoxin (penitrem A) in a dog

Area of Science:

• Veterinary Toxicology
• Mycology
• Food Safety

Background:

• Tremorgenic mycotoxins, such as penitrem A, are produced by fungi like Penicillium crustosum.
• Accidental ingestion of contaminated food can lead to severe neurological effects in animals.

Observation:

• A 1-year-old Siberian Husky developed severe muscle tremors following ingestion of a mouldy hamburger bun.
• Penicillium crustosum and penitrem A were identified in the uneaten portion of the bun.

Findings:

• The isolated Penicillium crustosum strain produced significant quantities of penitrem A and related compounds in pure culture.
• This case represents the first documented instance of penitrem A toxicosis in Australia.

Implications:

• Highlights the risk of mycotoxin contamination in food products, even in seemingly common items like hamburger buns.
• Underscores the importance of veterinary diagnostic capabilities for identifying novel or rare toxicological cases.
• Emphasizes the need for increased awareness regarding fungal toxins in animal feed and food safety regulations.