Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Nov 5, 2025

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.

J Blauensteiner¹, R Bertinat², L E León³

¹Institute of Biomedical Science, Department of Health Studies, FH Joanneum University of Applied Sciences, Graz, Austria.

Scientific Reports

|May 20, 2021

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lactic acid bacteria and their importance in the biopreservation of meat and meat product: a review.

Brazilian journal of biology = Revista brasleira de biologia·2026

Same author

A versatile chamber for x-ray scattering on liquid jets with sample recycling.

The Review of scientific instruments·2022

Same author

Gelation Dynamics upon Pressure-Induced Liquid-Liquid Phase Separation in a Water-Lysozyme Solution.

The journal of physical chemistry. B·2022

Same author

Publisher Correction: Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.

Scientific reports·2021

Same author

Shear-induced ordering in liquid microjets seen by x-ray cross correlation analysis.

Structural dynamics (Melville, N.Y.)·2020

Same author

Wave-Vector Dependence of the Dynamics in Supercooled Metallic Liquids.

Physical review letters·2020

This study found increased levels of specific microRNAs (miRs) in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggesting a role for endothelial dysfunction in the disease. These findings may help identify new biomarkers and therapeutic targets for ME/CFS.

Area of Science:

Immunology
Vascular Biology
Biomarker Discovery

Background:

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness with unknown causes, but immunological abnormalities and inflammation are implicated.
Endothelial dysfunction, involving the Sirt1/eNOS pathway, is a potential factor in ME/CFS pathogenesis.
MicroRNAs (miRs) are increasingly recognized as potential biomarkers for complex diseases.

Purpose of the Study:

To investigate the Sirt1/eNOS axis in ME/CFS by analyzing specific microRNAs (miRs) in patient plasma.
To identify potential circulating biomarkers related to endothelial dysfunction in ME/CFS.

Main Methods:

Analysis of plasma microRNA levels (miR-21, miR-34a, miR-92a, miR-126, miR-200c) in ME/CFS patients and healthy controls.

More Related Videos

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Related Experiment Videos

Last Updated: Nov 5, 2025

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Examination of public microRNA data from peripheral blood mononuclear cells.

Bioinformatics analysis to identify associated signaling pathways and regulatory networks.

Main Results:

Five specific microRNAs (miR-21, miR-34a, miR-92a, miR-126, miR-200c) were found to be significantly elevated in ME/CFS patients compared to controls.
Similar increases in these miRs were observed in public datasets of peripheral blood mononuclear cells.
Bioinformatics analysis linked these miRs to endothelial function, oxidative stress, and oxygen regulation pathways, with histone deacetylase 1 identified as a key regulatory node.

Conclusions:

The study identifies a set of microRNAs associated with endothelial dysfunction in ME/CFS.
These findings provide a foundation for developing novel biomarkers for ME/CFS.
The identified microRNAs and regulatory pathways represent potential therapeutic targets for ME/CFS.