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Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Cell Lines

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...

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Related Experiment Video

Updated: Nov 5, 2025

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

Tracking cell lineages to improve research reproducibility

Sophie Zaaijer^1,2, Simon C Groen³, Neville E Sanjana^4,5

¹Cornell Tech, New York, NY, USA. sophie@findgen.bio.

Nature Biotechnology

|May 20, 2021

Summary

No abstract available in PubMed .

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