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An interactive program on the PDP-11 for computing organ blood flow from data obtained using the radioactive

R B Lydic, S L Britton, D G Davies

    Computer Programs in Biomedicine
    |December 1, 1977
    PubMed
    Summary

    This program computes blood flow parameters in research animals using radioactive microspheres. It provides detailed organ-specific and systemic circulation data for enhanced physiological research.

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    Area of Science:

    • Physiology
    • Medical Imaging
    • Computational Biology

    Background:

    • The radioactive microsphere technique is crucial for measuring organ blood flow.
    • Accurate computation of various hemodynamic parameters is essential for physiological research.

    Purpose of the Study:

    • To describe an interactive BASIC-PLUS program for calculating blood flow parameters.
    • To facilitate data analysis from radioactive microsphere studies in research animals.

    Main Methods:

    • Development of an interactive program using BASIC-PLUS language.
    • Integration with the PDP-11 computer for data processing.
    • Utilized radioactive microsphere data for quantitative analysis.

    Main Results:

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    • The program outputs descriptive statistics, organ blood flow (total and per unit weight), and flow resistance.
    • Calculates total systemic arterial resistance and cardiac output.
    • Determines the percentage of cardiac output distributed to individual organs.

    Conclusions:

    • The developed program enhances the analysis of radioactive microsphere data.
    • Enables comprehensive assessment of blood flow dynamics in research animals.
    • Supports studies involving multiple isotopes for varied experimental conditions.