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The correlation between neonatal vitamin D levels and the risk of childhood asthma attacks

Wenlin Li1, Jin Zhou2, Shen Liu2

  • 1Department of Neonatology, Haikou Hospital of The Maternal And Child Health, Haikou, China.

Translational Pediatrics
|May 20, 2021
PubMed

Insights

Lower neonatal vitamin D levels are linked to a higher risk of childhood asthma. Maintaining adequate vitamin D in newborns may help prevent asthma development in children.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Investigating the association between vitamin D status in newborns and the development of asthma in early childhood.
  • Understanding the long-term health implications of neonatal nutrient levels.

Purpose of the Study:

  • To determine the correlation between neonatal 25-hydroxyvitamin D3 [25(OH)D3] levels and the risk of asthma in children aged 3-9 years.
  • To identify vitamin D as a potential independent risk factor for childhood asthma.

Main Methods:

  • A cohort of 1,534 subjects was analyzed, collecting neonatal data including 25(OH)D3 levels and various maternal and birth factors.
  • Cox proportional regression models were used to assess the correlation between 25(OH)D3 levels and asthma risk.
  • Subgroup analyses were performed based on gender and birth season.

Main Results:

  • Neonatal 25(OH)D3 levels were significantly lower in children who developed asthma compared to controls (P=0.03).
  • Higher quartiles of neonatal 25(OH)D3 were associated with a reduced risk of asthma, with the highest quartile showing a 50% reduction (HR=0.50).
  • The observed correlation remained significant after stratification by gender and birth season.

Conclusions:

  • Reduced vitamin D levels in newborns are significantly correlated with an increased risk of developing asthma by age 3-9 years.
  • Neonatal vitamin D status is identified as an independent risk factor for childhood asthma.
Abstract

Keywords:
Newbornsasthmachildrenvitamin D

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