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[Morphometric analysis of systematic colonic biopsies]
J L Salzmann1, F Peltier-Koch, F Bloch
1Service Central d'Anatomie Pathologique et INSERM U28, Hôpital Broussals, Paris.
Annales De Pathologie
|January 1, 1988
Abstract:
Using an automatic image analysis processor we measured the cellular density of the lamina propria and the mean glandular area on biopsies issued from 10 normal patients. The microscopic image was automatically digitalized and filtered. The operator manually traced the perimeter of the mucosal glands. The mean nucleus number for a 32,000 microns2 chorionic area is 177 +/- 24. The mean glandular area is 51.2 +/- 2.9%. This method is fast (2 min by field) and reproducible. It can be proposed for the study of inflammatory conditions on systematic colonic biopsy material.