The proteomic data of liver in mice with hyperlipidemia

Area of Science:

• Biochemistry
• Pharmacology
• Proteomics

Background:

• Atherosclerosis (AS) is a major cardiovascular disease, with hyperlipidemia (HLP) as its primary cause.
• Fructus Rosae Roxburghii (FRR) is recognized for its medicinal properties, including potential antiatherosclerotic effects, but its mechanism remains largely unknown.

Purpose of the Study:

• To investigate the molecular mechanisms underlying the antiatherosclerotic effects of FRR juice in diet-induced hyperlipidemic mice.
• To analyze the impact of FRR on lipid profiles and identify differentially expressed proteins in the liver.

Main Methods:

• Diet-induced hyperlipidemic mice were treated with FRR juice.
• Lipid profiles (Total Cholesterol, Triglyceride, LDL, HDL, ASI) were measured.
• Liver proteins were analyzed using TMT labeling and LC-MS/MS, followed by bioinformatics analysis of differentially expressed proteins and KEGG pathways.

Main Results:

• FRR juice significantly altered lipid profiles in hyperlipidemic mice.
• Proteomic analysis identified key differentially expressed proteins in the liver.
• Bioinformatics analysis revealed affected KEGG signaling pathways, providing insights into FRR's mechanism of action.

Conclusions:

• FRR juice demonstrates potential in ameliorating hyperlipidemia and associated atherosclerosis.
• The study elucidates the antiatherosclerotic mechanism of FRR by analyzing protein expression changes in the liver.
• These findings highlight FRR as a potential source for novel therapeutic targets against atherosclerosis.