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Updated: Nov 5, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Intelligent Cardiovascular Disease Prediction Empowered with Gradient Descent Optimization
Muhammad Saqib Nawaz1, Bilal Shoaib1, Muhammad Adeel Ashraf2
1Department of Computer Science, Minhaj University Lahore, Lahore, 54000, Pakistan.
Insights
This study introduces an optimized machine learning model for effective cardiovascular disease diagnosis. The Gradient Descent Optimization model achieved high accuracy, sensitivity, and precision, aiding in early detection and analysis.
Area of Science:
- Cardiology
- Medical Informatics
- Machine Learning
Background:
- Cardiovascular diseases are the leading global cause of death, claiming 17.9 million lives annually.
- Accurate and timely diagnosis of heart disease is critical for patient survival and effective treatment.
- Existing diagnostic methods can be enhanced with advanced computational approaches for improved outcomes.
Purpose of the Study:
- To develop an effective heart disease diagnosis system using machine learning algorithms.
- To optimize the diagnostic process for cardiovascular diseases through advanced algorithms.
- To evaluate the performance of various machine learning models in predicting heart disease.
Main Methods:
- Utilized the heart disease dataset from the UCI Machine Repository for analysis.
- Applied and compared several machine learning algorithms including Support Machine Vector (SVM), K-Nearest Neighbor (KNN), Naïve Bayes (NB), Artificial Neural Network (ANN), and Random Forest (RF).
- Implemented and evaluated a Gradient Descent Optimization (GDO) model for enhanced cardiovascular disease prediction.
Main Results:
- The Gradient Descent Optimization (GDO) based model demonstrated superior performance compared to other classification algorithms.
- Achieved an accuracy of 98.54% for the GDO model during performance evaluation.
- Recorded high sensitivity (recall) of 99.43% and precision of 97.76% with the proposed GDO model.
Conclusions:
- The developed GDO-empowered system shows significant potential for accurate cardiovascular disease diagnosis.
- The model's high accuracy and sensitivity make it a satisfactory tool for clinical use.
- This research contributes a valuable system for the analysis and prediction of cardiovascular diseases.
Abstract:
Disorders of the heart and blood vessels are named cardiovascular disease. 'The heart's proper functionality is of an utmost necessity for the survival of life. The death rate due to heart disease, has been increased rapidly. Cardiovascular illness is believed the deadliest cause of death across the globe. From the facts and figures shared by the WHO (World Health Organization) 17.9 Million human lost their lives due to cardiovascular diseases. This research is carried out for the effective diagnosis of heart disease using the heart disease dataset available on the UCI Machine Repository. Heart disease diagnosis with an optimization algorithm can be fruitful in terms of higher accuracy and sensitivity. Finding an acceptable optimal solution among multiple solutions for a specific problem is known as optimization. Different machine learning algorithms have been applied as Support Machine Vector (SVM), K-Nearest Neighbor (KNN), Naïve Bayes (NB), Artificial Neural Network (ANN), Random Forest (RF), and Gradient Descent Optimization (GDO). Intelligent Cardiovascular Disease Prediction Empowered with Gradient Descent Optimization model produces the optimal results among under consideration classification algorithms. 98.54 % accuracy has been achieved by the GDO based model while performance evaluation it. 99.43% sensitivity (recall) and 97.76% precision have also been recorded. From the prediction results of the system, it's satisfactory to utilize it for cardiovascular disease diagnosis. The proposed system will be helpful for the analysis of cardiovascular disease.
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