Related Experiment Video
Updated: Nov 5, 2025
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
1.1K
Outcomes of Hypertensive Kidney Donors Using Current and Past Hypertension Definitions
Hassan N Ibrahim1, Sean A Hebert1, Dina N Murad1
1Division of Renal Diseases, Hypertension and Transplantation, Houston Methodist Hospital, Houston, Texas, USA.
Kidney International Reports
|May 20, 2021
Summary
Kidney donors with hypertension, by older definitions, face similar risks for mortality, cardiovascular disease (CVD), and end-stage kidney disease (ESKD). Current hypertension criteria showed similar renal outcomes but increased CVD risk.
Area of Science:
- Nephrology
- Cardiology
- Transplant Surgery
Background:
- Hypertension is a common reason for excluding kidney donor candidates in the U.S.
- This exclusion is based on the known links between hypertension, kidney disease, and cardiovascular disease (CVD).
Purpose of the Study:
- To evaluate the long-term risks of mortality, CVD, and kidney disease in kidney donors with hypertension.
- To compare outcomes between hypertensive and normotensive kidney donors.
Main Methods:
- Retrospective analysis of 904 hypertensive donors (BP ≥140/90 mmHg or on treatment) and 7817 normotensive donors.
- Ascertainment of mortality, CVD, proteinuria, estimated glomerular filtration rate (eGFR) trajectory, and end-stage kidney disease (ESKD).
Main Results:
- Hypertensive donors were older and had lower baseline eGFR.
- Long-term follow-up (14.3 ± 10.1 years) showed similar rates of CVD and renal outcomes between hypertensive and normotensive donors.
- No significant difference in mortality, CVD, or ESKD risk was observed using older hypertension criteria; however, using newer criteria (BP ≥130/80 mmHg or on treatment), hypertensive donors had higher risks of CVD and diabetes.
Conclusions:
- Kidney donors with hypertension, by past definitions, do not face increased risks of mortality, CVD, or ESKD.
- Current hypertension definitions indicate similar renal outcomes but a higher likelihood of developing CVD in kidney donors.
More Related Videos
Related Concept Videos
01:28Kidney Transplant I: Introduction
105
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
105
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
166
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
166
01:18Hypertension and Regulation of Blood Pressure
3.4K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.4K
01:28Hypertension I: Introduction
260
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
260
01:26Kidney Transplant II: Surgical Procedure
109
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
109
01:25Chronic Kidney Disease I: Introduction
307
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
307