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Published on: September 15, 2017
A rare cause of salt-wasting in early infancy: Transient pseudohypoaldosteronism
Dilara Ceylan1, Elvan Bayramoğlu2, Emine Polat1
1Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Insights
Transient pseudohypoaldosteronism can occur in infants with urinary tract infections and malformations. Prompt diagnosis and treatment are crucial for resolving electrolyte imbalances in these cases.
Area of Science:
- Pediatrics
- Endocrinology
- Neonatology
Background:
- Infants with urinary tract infections (UTIs) and malformations can present with electrolyte abnormalities.
- Poor weight gain, hyponatremia, and hyperkalemia are key clinical signs.
- These symptoms necessitate a thorough differential diagnosis.
Abstract:
Three infants aged between 38 days and 43 days all presented with poor weight gain, hyponatremia, hyperkalemia, and were diagnosed as having urinary tract infections, which were accompanied by urinary tract malformations in our cases. Hydration and infection treatments were given. A few days after admission, hormonal studies revealed normal cortisol and 17-hydroxy progesterone levels and markedly high aldosterone levels, thus the patients were diagnosed as having transient pseudohypoaldosteronism. After the proper treatment was given, the transient pseudohypoaldosteronism resolved. In conclusion, when an infant with urinary tract infection or malformation has electrolyte abnormalities, pediatricians should consider the diagnosis of transient pseudohypoaldosteronism.
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