Osteoporosis was associated with severe abdominal aortic calcification based on a cross-sectional study
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Mingyue Wu1, Yihai Liu2, Chongxia Zhong1
1Department of Cardiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Insights
Osteoporosis is linked to severe abdominal aortic calcification (AAC). This finding in a US population suggests a potential independent association, aiding vascular disease prevention and management strategies.
Area of Science:
- Gerontology
- Cardiovascular Health
- Bone Metabolism
Background:
- Abdominal aortic calcification (AAC) and osteoporosis are common age-related conditions.
- Both diseases share underlying pathological mechanisms.
- The direct association between osteoporosis and AAC remains unclear.
Purpose of the Study:
- To investigate the relationship between osteoporosis and abdominal aortic calcification.
- To determine if osteoporosis is an independent risk factor for severe AAC.
Main Methods:
- Utilized data from 3134 participants in the NHANES 2013-2014 survey.
- AAC scores were calculated from dual-energy X-ray absorptiometry (DXA) scans.
- Osteoporosis diagnosis was based on self-reported interviews; multivariable logistic regression analyzed the association.
Main Results:
- Participants with osteoporosis exhibited higher AAC scores compared to those without.
- Osteoporosis was significantly associated with increased odds of severe AAC (OR = 2.65).
- This association remained significant after adjusting for multiple covariates (OR = 2.17).
Conclusions:
- Osteoporosis may be independently associated with severe abdominal aortic calcification.
- Findings contribute to understanding the link between bone health and vascular disease.
- This association could inform novel prevention and management strategies for cardiovascular conditions.
Abstract:
Abdominal aortic calcification and osteoporosis are age-related diseases. Based on a nationally representative US population, we concluded that osteoporosis may be independently associated with severe abdominal aortic calcification, which could improve our insights into the prevention and management of vascular disease.
Introduction:
Abdominal aortic calcification (AAC) and osteoporosis are age-related diseases and share similar pathological mechanisms. However, the association between osteoporosis and AAC is uncertain.
Methods:
A total of 3134 participants with complete record of AAC score calculated from dual-energy X-ray absorptiometry (DXA) were enrolled from the National Health and Nutrition Examination Survey (NHANES) 2013-2014. The diagnosis of osteoporosis was obtained from self-reported interview. The baseline covariates were compared between participants with and without osteoporosis. Multivariable logistic regression was performed to examine the association between abdominal aortic calcification and osteoporosis.
Results:
Compared with those without osteoporosis, participants with osteoporosis had higher AAC scores. Osteoporosis was positively associated with higher odds of severe AAC (OR = 2.65; 95%CI, 1.89-3.71; P < 0.001), and the association was not altered (OR = 2.17; 95%CI, 1.23-3.83; P = 0.008) after adjusting for numerous covariates.
Conclusions:
Our findings suggest that osteoporosis may be independently associated with severe abdominal aortic calcification.
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