Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic experiments with clotrimazole administered orally.

M Seo, H iida, Y Miura

    Current Medical Research and Opinion
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography.

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·1996
    Same author

    Noninvasive quantification of regional myocardial metabolic rate for oxygen by use of 15O2 inhalation and positron emission tomography. Theory, error analysis, and application in humans.

    Circulation·1996
    Same author

    Noninvasive quantification of regional myocardial metabolic rate of oxygen by 15O2 inhalation and positron emission tomography. Experimental validation.

    Circulation·1996
    Same author

    Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine.

    European journal of nuclear medicine·1996
    Same author

    [Development of a front shield for a 3D positron emission tomograph].

    Kaku igaku. The Japanese journal of nuclear medicine·1996
    Same author

    Glucose uptake in the chronically dysfunctional but viable myocardium.

    Circulation·1996
    Same journal

    BMI response to dapagliflozin with or without semaglutide across obesity classes: a real-world observational study conducted in Saudi Arabia.

    Current medical research and opinion·2026
    Same journal

    Comparative efficacy of tislelizumab + FOLFOX or CAPOX for gastric/gastroesophageal junction adenocarcinoma: an exploratory matching-adjusted indirect comparison.

    Current medical research and opinion·2026
    Same journal

    Seizing the opportune moment: early use of antiplatelet therapy for thrombolysis.

    Current medical research and opinion·2026
    Same journal

    The importance of patient life engagement as a treatment goal in adults living with schizophrenia: a plain language summary.

    Current medical research and opinion·2026
    Same journal

    A systematic review of indirect treatment comparisons among recently approved chimeric antigen receptor T-cell and bispecific antibody therapies for triple-class exposed relapsed/refractory multiple myeloma.

    Current medical research and opinion·2026
    Same journal

    Enabling remuneration for patient authors of company-sponsored publications: approaches and case study examples aligned with Good Publication practice.

    Current medical research and opinion·2026
    See all related articles

    Clotrimazole showed varying minimum inhibitory concentrations (MICs) against Candida albicans serotypes. Oral clotrimazole tablets were poorly absorbed, but an oil solution achieved effective blood levels against fungal infections.

    Area of Science:

    • Mycology
    • Pharmacology
    • Antimicrobial Agents

    Background:

    • Clotrimazole is an antifungal medication used to treat various fungal infections.
    • Understanding its efficacy and pharmacokinetic profile is crucial for optimizing treatment strategies.

    Purpose of the Study:

    • To determine the minimum inhibitory concentrations (MICs) of clotrimazole against different yeast strains.
    • To evaluate the blood levels of clotrimazole after oral administration in tablet and oil solution forms.

    Main Methods:

    • Determination of MICs for clotrimazole against yeast and mycelial forms of Candida albicans serotypes A and B.
    • Administration of clotrimazole orally via tablets and oil solutions to assess blood, urine, and fecal levels.

    Main Results:

    Related Experiment Videos

    • Significant differences in MICs were observed between Candida albicans serotypes A and B in their yeast form, with Type B requiring a higher concentration.
    • The mycelial form showed lower MICs with minimal difference between serotypes.
    • Oral tablet administration resulted in poor absorption, low blood and urinary levels, and high fecal excretion.
    • Clotrimazole in an oil solution achieved significantly higher blood levels compared to tablets, with effective concentrations maintained even at 250 mg dosage.

    Conclusions:

    • Clotrimazole's antifungal activity varies based on Candida albicans morphology and serotype.
    • Oral tablet formulation leads to suboptimal systemic absorption.
    • An oil-based formulation enhances clotrimazole's bioavailability, achieving therapeutically relevant blood levels for treating systemic fungal infections.