Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic digitalis-like substance is released with sodium-loading in rats.

H Takahashi1, M Matsusawa, K Suga

  • 12nd Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

American Journal of Hypertension
|April 1, 1988
PubMed
Summary

High sodium intake increases blood pressure and the release of hypothalamic digitalis-like substance (EDLS). Lesioning the AV3V area reduces both, suggesting EDLS plays a role in sodium-induced hypertension.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acinar cell carcinoma of the pancreas with elevated serum alpha-fetoprotein levels: a case report and a review of 28 cases reported in Japan.

Gastroenterologia Japonica·1992
Same author

[Coagulation and fibrinolysis in pregnancy].

Rinsho byori. The Japanese journal of clinical pathology·1992
Same author

[Elevated production of GM-CSF by peripheral blood mononuclear cells stimulated with mite antigens in children with bronchial asthma].

Arerugi = [Allergy]·1992
Same author

[A survey of body temperatures in the elderly and the thermal environment in nursing homes].

[Nihon koshu eisei zasshi] Japanese journal of public health·1992
Same author

[Health status and care of the urban elderly].

[Nihon koshu eisei zasshi] Japanese journal of public health·1992
Same author

[A study of falls experienced by institutionalized elderly].

[Nihon koshu eisei zasshi] Japanese journal of public health·1992

Area of Science:

  • Neuroendocrinology
  • Cardiovascular Physiology

Background:

  • Hypertension is a complex condition often linked to dietary factors like excess sodium intake.
  • The brain, particularly the hypothalamus, plays a crucial role in regulating blood pressure and fluid balance.

Purpose of the Study:

  • To investigate the role of hypothalamic digitalis-like substance (EDLS) in sodium-induced hypertension.
  • To explore the mechanisms regulating EDLS release in response to sodium.

Main Methods:

  • Rats were fed a high-sodium diet, and blood pressure and urinary EDLS were monitored.
  • Electrical lesions were made in the AV3V area of the hypothalamus.
  • Immunohistochemistry was used to localize EDLS in the brain.
  • Hypertonic NaCl was infused into the lateral ventricle and continuously via osmotic minipumps.

Related Experiment Videos

Main Results:

  • High sodium intake significantly increased blood pressure and urinary EDLS.
  • AV3V lesions reduced both blood pressure and urinary EDLS.
  • Central administration of hypertonic NaCl increased plasma EDLS and arterial pressure, while hypothalamic EDLS decreased.

Conclusions:

  • Hypothalamic EDLS is implicated in the development of hypertension associated with excess sodium intake.
  • Cerebrospinal fluid sodium concentration may be a trigger for EDLS release.
  • The AV3V area is critical for mediating these effects.