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Precocious Puberty in Boys: A Study Based on Five Years of Data from a Single Center in Northern China

Liu Ziqin1,2, Li Xiaohui2,3, Chen Xiaobo1

  • 1Children’s Hospital Capital Institute of Pediatrics, Clinic of Endocrinology, Beijing, China

Journal of Clinical Research in Pediatric Endocrinology
|May 20, 2021
PubMed

Insights

Precocious puberty (PP) in Chinese boys is often idiopathic central PP. Peripheral PP causes include congenital adrenal hyperplasia and germ cell tumors.

Area of Science:

  • Pediatric Endocrinology
  • Reproductive Health
  • Clinical Research

Background:

  • Precocious puberty (PP) is a condition characterized by early onset of pubertal development.
  • Understanding the diverse etiologies of PP is crucial for accurate diagnosis and management in pediatric populations.

Purpose of the Study:

  • To investigate the clinical features and etiological factors of precocious puberty (PP) specifically in Chinese boys.
  • To differentiate between central precocious puberty (CPP) and peripheral precocious puberty (PPP) in this cohort.

Main Methods:

  • Retrospective analysis of data from boys diagnosed with PP between 2015 and 2020.
  • Inclusion of patients referred to a tertiary hospital in Northern China for PP evaluation.

Main Results:

  • Eighty-two boys were diagnosed with PP.
  • Central precocious puberty (CPP) accounted for 75.6% of cases, with 49 being idiopathic and 13 pathogenic.
  • Peripheral precocious puberty (PPP) comprised 24.4%, with congenital adrenal hyperplasia, germ cell tumors, and familial male-limited PP as leading causes.

Conclusions:

  • The etiology of PP in males is varied.
  • Idiopathic cases constitute the majority of central precocious puberty in Chinese boys, highlighting the need for careful evaluation to rule out organic causes.
Abstract

Keywords:
Maleprecocious pubertyetiology

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