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Size-transformable nanohybrids with pH/redox/enzymatic sensitivity for anticancer therapy.

Bozhen Wu1, Mingpei Li1, Liudi Wang2

  • 1College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Journal of Materials Chemistry. B
|May 20, 2021
PubMed
Summary

This study presents a novel nanocarrier system that enhances tumor penetration and drug delivery for cancer treatment. The pH/redox/enzymatic-sensitive nanohybrid system improves intracellular delivery and antitumor effects.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Limited clinical applications of nanocarriers in cancer therapy due to poor tumor penetration and low delivery efficiency.
  • Tumor microenvironment (TME)-responsive drug delivery systems offer targeted drug release for improved therapeutic outcomes.

Purpose of the Study:

  • To develop a biodegradable, multi-sensitive nanohybrid drug delivery system for enhanced cancer treatment.
  • To investigate the TME-responsive drug release and combined therapeutic potential of the developed nanosystem.

Main Methods:

  • Assembly of bovine serum albumin (BSA) nano-units onto graphene oxide (GO) nanosheets using gelatin.
  • Characterization of nanoparticle stability under physiological conditions and drug release triggered by TME-specific stimuli (pH, redox, enzymes).
  • Evaluation of combined chemotherapy (doxorubicin release) and photothermal therapy (near-infrared light) in a tumor model.

Main Results:

  • The nanohybrid system demonstrated stability under physiological conditions and released BSA nano-units upon protease triggering.
  • Acidic, reductive, and enzymatic TME conditions effectively triggered doxorubicin (DOX) release.
  • The system facilitated combined chemotherapy and photothermal therapy, showing potential for enhanced antitumor bioactivity.

Conclusions:

  • The developed pH/redox/enzymatic-sensitive nanohybrid system effectively targets the tumor microenvironment for controlled drug release.
  • The nanosystem shows promise in improving tumor penetration, intracellular drug delivery, and combining chemotherapy with photothermal therapy for enhanced anticancer efficacy.