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T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: Nov 5, 2025

Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs

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CD1a autoreactivity: When size does matter.

Laurent Gapin^1,2

¹Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.

The Journal of Experimental Medicine

|May 20, 2021

Summary

This summary is machine-generated.

CD1a-autoreactive T cells in humans are regulated by specific lipid interactions. CD1a molecules capture lipids, preventing autoreactive T cell antigen receptors from binding, offering new therapeutic targets.

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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Published on: October 12, 2018

Area of Science:

Immunology
Cell Biology
Biochemistry

Background:

CD1a-autoreactive T cells are abundant in human circulation and skin.
The regulatory mechanisms of CD1a autoreactivity are not fully understood.

Purpose of the Study:

To investigate how CD1a molecules interact with cellular lipids and influence autoreactive T cell responses.

Main Methods:

Analysis of CD1a molecule interactions with various lipid classes.
Assessment of the impact of these interactions on autoreactive T cell antigen receptor binding.

Main Results:

CD1a molecules selectively capture specific lipid classes.
This lipid capture mechanism interferes with autoreactive T cell antigen receptor binding to CD1a.

Conclusions:

CD1a autoreactivity is regulated through selective lipid binding by CD1a molecules.
These findings suggest novel therapeutic strategies for modulating CD1a autoreactive T cell responses.