Related Experiment Video
Updated: Nov 5, 2025
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3DBionotes COVID-19 edition
Jose Ramon Macias1, Ruben Sanchez-Garcia1, Pablo Conesa1
1Spanish National Bioinformatics Institute (INB ELIXIR-ES), Biocomputing Unit, National Centre of Biotechnology (CNB-CSIC), Instruct Image Processing Centre, Campus de Cantoblanco, 28049 Madrid, Spain.
Summary:
The web platform 3DBionotes-WS integrates multiple web services and an interactive web viewer to provide a unified environment in which biological annotations can be analyzed in their structural context. Since the COVID-19 outbreak, new structural data from many viral proteins have been provided at a very fast pace. This effort includes many cryogenic electron microscopy (cryo-EM) studies, together with more traditional ones (X-rays, NMR), using several modeling approaches and complemented with structural predictions. At the same time, a plethora of new genomics and interactomics information (including fragment screening and structure-based virtual screening efforts) have been made available from different servers. In this context, we have developed 3DBionotes-COVID-19 as an answer to: (i) the need to explore multiomics data in a unified context with a special focus on structural information and (ii) the drive to incorporate quality measurements, especially in the form of advanced validation metrics for cryo-EM.
Availability And Implementation:
https://3dbionotes.cnb.csic.es/ws/covid19.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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