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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Different Tumor Microenvironments Lead to Different Metabolic Phenotypes.

Marjorie Justine Antonio1, Cissy Zhang1,2, Anne Le3,4

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Advances in Experimental Medicine and Biology
|May 20, 2021
PubMed
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The tumor microenvironment (TME) is crucial for cancer progression. Understanding how TMEs influence cancer cell metabolism offers new therapeutic strategies for heterogeneous cancers.

Keywords:
Fatty acid oxidationHeterogeneity of cancerMetabolic phenotypesMetabolic processesTumor microenvironments

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Area of Science:

  • Oncology
  • Cancer Biology
  • Metabolic Research

Background:

  • The tumor microenvironment (TME) is a complex ecosystem supporting cancer cell survival and proliferation.
  • Advances in cancer research have illuminated the critical role of the TME in tumor development.
  • Cancer cell heterogeneity poses significant challenges for effective treatment strategies.

Purpose of the Study:

  • To discuss the relationship between diverse tumor microenvironments and cancer metabolic adaptations.
  • To explore how metabolic changes within the TME drive cancer progression.
  • To highlight the impact of TME-driven metabolism on cancer heterogeneity.

Main Methods:

  • Literature review of recent advances in tumor microenvironment research.
  • Analysis of metabolic pathways influenced by varying TME conditions.
  • Synthesis of data on cancer cell adaptation to the TME.

Main Results:

  • Different TMEs induce specific metabolic adaptations in cancer cells.
  • These metabolic shifts are integral to cancer progression and heterogeneity.
  • The TME's dynamic nature necessitates adaptive metabolic strategies by cancer cells.

Conclusions:

  • Targeting TME-specific metabolic adaptations presents a promising avenue for cancer therapy.
  • Understanding metabolic reprogramming within the TME is key to overcoming cancer heterogeneity.
  • Further research into the TME-metabolism interplay can lead to novel treatment approaches.