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Dinitrosyl Iron Complexes (DNICs). From Spontaneous Assembly to Biological Roles
Daniela R Truzzi1, Nathalia M Medeiros1, Ohara Augusto1
1Departamento de Bioquímica, Instituto de Química de São Paulo, Universidade de São Paulo, Caixa Postal 26077, CEP05513-970 São Paulo, São Paulo, Brazil.
Inorganic Chemistry
|May 20, 2021
Summary
Dinitrosyl iron complexes (DNICs) form rapidly in cells from nitric oxide (NO) and biothiols. Understanding DNIC chemical biology and reactivity is key to their role in health and disease.
Area of Science:
- Biochemistry
- Cell Biology
- Chemical Biology
Background:
- Dinitrosyl iron complexes (DNICs) are rapidly formed in cells, requiring nitric oxide (NO), biothiols, and iron.
- Electron paramagnetic resonance (EPR) ubiquitously detects DNICs in NO-producing cells, yet their chemical biology is not fully understood.
- The precise mechanisms and physiological roles of endogenous DNICs remain an active area of research.
Purpose of the Study:
- To elucidate the reaction mechanisms of endogenous DNIC formation, emphasizing a labile iron pool as the iron source.
- To discuss the role of DNICs in promoting S-nitrosation and generating S-nitrosothiols.
- To highlight the importance of understanding DNIC chemical reactivity and dynamics for physiological and pathological insights.
Main Methods:
- Focus on reaction mechanisms for endogenous DNIC formation.
- Investigation of DNICs' capability to promote S-nitrosation.
- Discussion of DNIC chemical reactivity and dynamics.
Main Results:
- Identified labile iron pools as a key iron source for endogenous DNIC formation.
- Detailed the association between DNIC formation, chemical reactivity, and S-nitrosothiol generation.
- Emphasized the link between DNIC S-nitrosation activity and cellular processes.
Conclusions:
- Elucidating DNIC formation mechanisms, particularly from labile iron, is crucial.
- DNICs play a significant role in S-nitrosation, impacting cellular signaling.
- Further research into DNIC reactivity and detection methods will illuminate their physiological and pathological relevance.
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