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Updated: Nov 5, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Serum survivin is decreased in women with preeclampsia

Onur Güralp1, Koray Gök2, Nevin Tüten3

  • 1Klinikum Oldenburg Aör, Carl Von Ossietzky Oldenburg University, University Hospital for Gynecology and Obstetrics, Oldenburg, Germany.

Hypertension in Pregnancy
|May 20, 2021
PubMed

Objective: To evaluate the serum survivin level in preeclampsia.Methods: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated.Results: Mean serum survivin was detected to be significantly decreased in the early- (EOPE) and late-onset (LOPE) preeclampsia subgroups than the GA-matched control-groups; and were comparable in EOPE- and LOPE-groups after correction for GA. Serum survivin had weak negative correlations with systolic and diastolic arterial blood pressure.Conclusion: The serum survivin level was decreased in preeclamptic patients than the GA-matched controls. More comprehensive studies are needed to clarify the timing and extent of placental apoptosis in preeclampsia.

Keywords:
Survivinapoptosisearly-onset preeclampsiahypertensionlate-onset preeclampsia

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