Related Experiment Video
Updated: Nov 5, 2025
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
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TRP channels in cancer pain
Amanda Spring de Almeida1, Laura de Barros Bernardes1, Gabriela Trevisan1
1Programa de Pós-Graduação Em Farmacologia, Universidade Federal de Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil.
European Journal of Pharmacology
|May 20, 2021
Summary
Transient receptor potential (TRP) channels, specifically TRPV1 and TRPA1, are key players in cancer pain. Targeting these channels shows promise for new pain management strategies beyond opioids.
Area of Science:
- Oncology
- Pain Research
- Molecular Biology
Background:
- Chronic pain, including cancer-induced bone pain (CIBP), significantly complicates cancer progression and patient prognosis.
- Opioid-based pharmacotherapy is the standard for cancer pain but carries adverse effects.
- Transient receptor potential (TRP) channels, particularly TRPV1 and TRPA1, are implicated in pain signaling.
Purpose of the Study:
- To review the role of TRPV1 and TRPA1 in the mechanisms of cancer pain.
- To explore TRP channels as potential therapeutic targets for cancer pain management.
Main Methods:
- Review of existing studies investigating TRPV1 and TRPA1 in various cancer pain models.
- Analysis of data from preclinical models involving tumor cell inoculation in mice and rats.
- Examination of clinical trial data for TRPV1 agonists in cancer pain.
Main Results:
- TRPV1 and TRPA1 agonists/antagonents and knockdown strategies reduced nociception in cancer pain models.
- TRPV1 is implicated in CIBP, with enhanced expression observed in some models.
- TRP channel involvement was demonstrated across diverse cancer pain models (bone, paw, mammary, nerve).
Conclusions:
- TRP channels, including TRPV1 and TRPA1, are significantly associated with cancer pain mechanisms.
- Targeting TRP channels represents a promising avenue for developing novel, non-opioid cancer pain therapies.
- Resiniferatoxin, a TRPV1 agonist, has shown preliminary positive results in clinical trials for cancer pain.
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