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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
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Ebolabase: Zaire ebolavirus-human protein interaction database for drug-repurposing.
Mathavan Muthaiyan1, Leimarembi Devi Naorem1, Vassavi Seenappa2
1Centre for Bioinformatics, Pondicherry University, Puducherry-605014, India.
International Journal of Biological Macromolecules
|May 20, 2021
Summary
This study curates Ebola-Human-Drug interactions by analyzing protein networks. The developed Ebolabase aids researchers in identifying repurposed drugs for Ebola Virus (EBOV) treatment.
Area of Science:
- Virology
- Bioinformatics
- Drug Discovery
Background:
- Ebola Virus (EBOV) causes severe hemorrhagic fever.
- Existing Ebola-human interaction data lacks comprehensive models and accessible resources.
- There is a need to curate Ebola-human-drug interactions for effective treatment strategies.
Purpose of the Study:
- To create a comprehensive resource for Ebola-human-drug interactions.
- To identify potential drug targets and repurposed drugs for EBOV treatment.
- To develop an integrated database for Ebola research.
Main Methods:
- Collected data on 270 human proteins interacting with EBOV from published literature.
- Generated protein-protein interaction networks for EBOV-human and EBOV-human-drug interactions.
- Performed gene enrichment and pathway analysis.
Main Results:
- Developed Ebolabase, an integrated database of Ebola-human-drug interactions.
- Identified potential drug targets and facilitated drug repurposing for EBOV.
- Provided visualized networks and downloadable data for researchers.
Conclusions:
- Ebolabase serves as a valuable resource for the Ebola research community.
- The study highlights the significance of human-based drug-targeted therapy in drug repurposing for EBOV.
- Investigating interaction networks aids in identifying suitable drug targets for Ebola treatment.
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