Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

724
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
724
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.7K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.7K
Olfaction01:25

Olfaction

46.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
46.5K
Lateralization01:28

Lateralization

693
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
693
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

5.5K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
5.5K
Association Areas of the Cortex01:21

Association Areas of the Cortex

7.3K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ins and outs of unpacking the black box: Understanding motivation using a multi-level approach.

The Behavioral and brain sciences·2025
Same author

Challenge or threat? A Q-methodological study into nursing students' perceptions on learning to collaborate under stress.

Nurse education today·2024
Same author

Evaluation of propofol-based procedural sedation in pediatric hemato-oncological patients provided by physician assistants in anesthesia.

Paediatric anaesthesia·2024
Same author

High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial).

Trials·2024
Same author

Food-related exploration across the menstrual cycle.

Appetite·2024
Same author

False aminoglycoside resistance in Enterobacterales and non-fermenters by an automated testing system: a descriptive study.

Microbiology spectrum·2024
Same journal

Double dissociation in the involvement of noradrenergic and endocannabinoid systems in classical and higher-order conditioning in newborn rabbits.

Neurobiology of learning and memory·2026
Same journal

An occasion for reflection: Pavlovian modulation of conditioned responding by interoceptive drug stimuli.

Neurobiology of learning and memory·2026
Same journal

Chemogenetic disruption of the hippocampus impairs gustatory preconditioning in rats.

Neurobiology of learning and memory·2026
Same journal

Corrigendum to "Dynamic regulation of neuronal vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5" [Neurobiol. Learn. Memory 225 (2026) 108161].

Neurobiology of learning and memory·2026
Same journal

Modeling the coexistence of NMDAR-dependent LTP and LTD mediated by changes in AMPAR conductance.

Neurobiology of learning and memory·2026
Same journal

No evidence for a protein-synthesis-dependent form of long-term fear memory: Translational inhibition and neural inactivation disrupt short- and long-term memory measures to the same degree.

Neurobiology of learning and memory·2026
See all related articles

Related Experiment Video

Updated: Nov 5, 2025

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

20.6K

Novelty processing depends on medial temporal lobe structures.

J Schomaker1, M M E Grouls2, C G M van der Linden1

  • 1Faculty of Social Sciences, Leiden University, the Netherlands.

Neurobiology of Learning and Memory
|May 20, 2021
PubMed
Summary
This summary is machine-generated.

The medial temporal lobe (MTL) is crucial for detecting and processing novel stimuli. MTL resections impair novelty detection and processing, but not target stimulus processing.

Keywords:
EpilepsyHippocampusMedial temporal lobeNovelty processingResection

More Related Videos

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

75.4K
Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
05:57

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

57.5K

Related Experiment Videos

Last Updated: Nov 5, 2025

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

20.6K
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

75.4K
Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
05:57

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

57.5K

Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • The medial temporal lobe (MTL) plays a significant role in memory and cognitive functions.
  • Understanding the MTL's specific contributions to novelty processing is essential for comprehending brain function.

Purpose of the Study:

  • To investigate the role of the medial temporal lobe (MTL) in the detection and subsequent processing of novelty.
  • To compare novelty processing in epilepsy patients with MTL resections and healthy controls.

Main Methods:

  • Utilized a visual novelty oddball task with electroencephalogram (EEG) recordings.
  • Compared 21 epilepsy patients with unilateral MTL resections to 26 matched healthy controls.
  • Analyzed event-related potential (ERP) components, specifically N2 and P3, associated with novelty detection and processing.

Main Results:

  • MTL resections significantly reduced novelty detection, indicated by a smaller N2 component.
  • Later processing of novel stimuli was impaired, particularly for stimuli presented contralateral to the resected MTL, shown by reduced novelty P3.
  • Target stimulus processing (P3b) remained unaffected in patients with MTL resections, highlighting the specificity of MTL involvement in novelty.

Conclusions:

  • Medial temporal lobe structures are integral to novelty detection and processing.
  • MTL resections specifically impact novelty processing, leaving the processing of target stimuli intact.