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Emerging roles of long non-coding RNAs in allotransplant rejection

Yao Teng1, Zhenli Huang1, Lan Yao1

  • 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Transplant Immunology
|May 20, 2021
PubMed

Insights

Long noncoding RNAs (lncRNAs) show altered expression in organ transplant rejection. These dysregulated lncRNAs impact immune cells and may serve as diagnostic biomarkers and therapeutic targets for post-transplant patients.

Area of Science:

  • Immunology
  • Genomics
  • Transplantation Science

Background:

  • Allotransplantation is crucial for end-stage organ failure and tumors.
  • Post-transplant rejection causes significant morbidity and mortality.
  • Current diagnostic criteria and therapies for rejection are limited.

Purpose of the Study:

  • To review the functions of long noncoding RNAs (lncRNAs) in immune cells relevant to allotransplant rejection.
  • To explore the regulatory roles of lncRNAs in patients with or without allograft rejection.
  • To discuss the potential of lncRNAs as diagnostic biomarkers and therapeutic targets.

Main Methods:

  • Review of studies utilizing high-throughput RNA sequencing.
  • Analysis of lncRNA expression in various biological samples (biopsies, blood, plasma, urine) and immune cells.
  • Examination of regulatory interactions of lncRNAs in transplant recipients.

Main Results:

  • Dysregulated lncRNAs are evident in rejecting patients.
  • lncRNAs affect immune cell function and differentiation.
  • Specific lncRNAs are associated with allograft rejection outcomes.

Conclusions:

  • lncRNAs play a significant role in the immune response following allotransplantation.
  • lncRNAs hold promise as molecular biomarkers for diagnosing post-transplant rejection.
  • lncRNAs represent potential novel therapeutic targets for managing transplant rejection.
Keywords:
Allotransplant rejectionImmune cellsTransplantationlncRNAs

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