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Related Experiment Video

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In phantom evaluation of targeting accuracy in MRI-based brain radiosurgery.

S Calusi1, C Arilli2, E Mussi3

  • 1Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Italy; National Institute of Nuclear Physics, Florence, Italy.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|May 20, 2021
PubMed
Summary

This study evaluated brain radiosurgery targeting accuracy using MRI-only versus MRI + CT imaging. Both methods achieved comparable accuracy, with the novel BrainTool phantom proving effective for testing.

Keywords:
3D MR image distortion phantom3D printingBrain phantomMR/CT imaging quality controlStereotactic radiosurgery accuracy

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Area of Science:

  • Medical Imaging
  • Neurosurgery
  • Radiotherapy

Background:

  • Accurate targeting is crucial for effective and safe brain radiosurgery.
  • Different imaging modalities, including Magnetic Resonance Imaging (MRI) and Computed Tomography (CT), are used for treatment planning.
  • Image co-registration and potential distortions can impact precision.

Purpose of the Study:

  • To assess the targeting accuracy of brain radiosurgery planning using MRI-only versus combined MRI + CT protocols.
  • To evaluate the performance of a novel phantom, the BrainTool, in assessing image co-registration and targeting accuracy.

Main Methods:

  • A 3D-printed BrainTool phantom was developed to simulate realistic brain anatomy and imaging contrast.
  • The phantom incorporated markers for co-registration accuracy and cavities for ionization chambers to measure targeting accuracy.
  • Two planning scenarios were tested: MRI-only and MRI + CT (1.5T and 3T scanners).
  • MR image distortions were pre-assessed using a GammaTool phantom.

Main Results:

  • MR image distortions were minimal, with average and maximum values of 0.3 mm and 1 mm, respectively.
  • Co-registered marker distances were below 0.5 mm for both MRI sequences.
  • Targeting mismatches were 0.8 mm for MRI-only, 1.0 mm for MRI + CT (1.5T), and 1.2 mm for MRI + CT (3T).

Conclusions:

  • Image-guided brain radiosurgery planning using combined MRI + CT yields targeting accuracies comparable to MRI-only approaches.
  • The BrainTool phantom is a suitable and effective tool for evaluating co-registration and targeting accuracy in Gamma Knife radiosurgery.