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Related Experiment Video

Updated: Nov 5, 2025

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
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Multi-photon absorption organotin complex for bioimaging and promoting ROS generation.

Changting Cai1, Mengqi Lv2, Pan Xiang2

  • 1Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Anhui University, Hefei 230601, PR China.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|May 20, 2021
PubMed
Summary

Researchers developed a new organotin compound (HSnBu3) for multiphoton imaging. This agent shows potential for deep tissue imaging and photodynamic therapy due to its efficient generation of singlet oxygen.

Keywords:
Fluorescence imagingMulti-photonOrganotin complexROS

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Area of Science:

  • Bio-imaging and photodynamic therapy

Background:

  • Multi-photon fluorescent dyes offer superior tissue penetration and reduced auto-fluorescence compared to conventional dyes.
  • Efficient multiphoton imaging agents are crucial for deep tissue visualization in biological research.

Purpose of the Study:

  • To design and synthesize a novel organotin derivative with multiphoton absorption capabilities.
  • To evaluate the potential of the synthesized compound as an imaging agent and for photodynamic therapy.

Main Methods:

  • Synthesis of an organotin derivative (HSnBu3).
  • Assessment of multiphoton absorption activity under near-infrared (NIR) excitation.
  • Evaluation of singlet oxygen (1O2) generation and cellular effects in HepG2 cells.

Main Results:

  • The synthesized organotin complex (HSnBu3) demonstrated significant three-photon activity at 1500 nm, unlike its ligand.
  • HSnBu3 efficiently generates singlet oxygen (1O2) upon activation by oxygen.
  • The compound induced a decrease in mitochondrial membrane potential in HepG2 cells.

Conclusions:

  • The organotin derivative HSnBu3 exhibits promising multiphoton absorption properties for deep tissue imaging.
  • HSnBu3 shows potential as a photosensitizer for photodynamic therapy due to its efficient 1O2 generation.