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Related Concept Videos

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Cell Motility through Blebbing01:16

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
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Role of Myosin in Cell Migration01:18

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Mechanism of Lamellipodia Formation01:31

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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Related Experiment Video

Updated: Nov 5, 2025

Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis
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Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis

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Basement membrane remodeling guides cell migration and cell morphogenesis during development.

David R Sherwood1

  • 1Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA; Regeneration Next, Duke University, Durham 27710, USA.

Current Opinion in Cell Biology
|May 20, 2021
PubMed
Summary
This summary is machine-generated.

Basement membranes (BMs) actively remodel to guide cell movement and shape during animal development. This extracellular matrix is crucial for directing cell migration, orientation, and neural development.

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Extracellular Matrix Research

Background:

  • Basement membranes (BMs) are essential extracellular matrix structures supporting animal tissues.
  • BMs provide critical signaling, mechanical, and barrier functions.
  • Cells interact with BMs for migration, shape changes, and process extension.

Purpose of the Study:

  • To provide an overview of recent findings on basement membrane remodeling.
  • To highlight how BM modifications actively guide cell behavior during development.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies on cell-matrix interactions in developmental contexts.

Main Results:

  • Basement membranes are not passive but are actively remodeled.
  • BM remodeling directs diverse cellular processes, including migration and morphogenesis.
  • Specific examples include guiding cell orientation, axon guidance, and dendrite branching.

Conclusions:

  • Active basement membrane remodeling is a key mechanism in animal development.
  • Understanding BM dynamics is crucial for comprehending cell motility and tissue formation.