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Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
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Moraxella nonliquefaciens superinfecting herpes simplex keratitis
Carmen Alejandra Porcar Plana1, Jaime Matarredona Muñoz1, Jaime Moya Roca1
1Opthalmology Department, Virgen de los Lirios Hospital, Alcoi, Spain.
European Journal of Ophthalmology
|May 21, 2021
Summary
Moraxella nonliquefaciens rarely causes eye infections. This report details the first case of M. nonliquefaciens keratitis superinfecting herpes simplex keratitis, highlighting the importance of prompt treatment.
Area of Science:
- Ophthalmology
- Microbiology
Background:
- Moraxella nonliquefaciens is a low-pathogenicity organism rarely causing ocular infections.
- Ocular M. nonliquefaciens infections typically manifest as endophthalmitis; corneal infections are exceptionally rare.
Observation:
- A case of a superinfected herpes simplex keratitis in an 84-year-old woman is presented.
- The patient developed a deep paracentral corneal infiltrate and hypopyon, with M. nonliquefaciens identified as the causative agent.
Findings:
- Successful treatment involved adjusting antibiotic therapy to ciprofloxacin and ceftazidime, alongside oral acyclovir and topical steroids.
- The patient achieved a final visual outcome of 20/50 with a clear cornea and a paracentral leucoma after four months.
Implications:
- This case underscores the importance of considering M. nonliquefaciens keratitis in patients with pre-existing corneal conditions.
- Prompt and combined treatment for underlying and superinfecting pathogens is crucial for favorable outcomes in rare microbial keratitis cases.
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