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Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5

Clint L Miller1, Amy R Kontorovich2, Ke Hao3

  • 1Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Journal of the American College of Cardiology
|May 21, 2021
PubMed

Insights

Precision medicine offers tailored treatments for vascular diseases. This seminar explores approaches for complex atherosclerosis and single-gene Mendelian vascular diseases, highlighting genetic differences.

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Precision Medicine

Background:

  • Atherosclerosis is a complex genetic vascular disease, a leading cause of heart disease and stroke.
  • Mendelian vascular diseases result from single genetic mutations with significant impact.
  • Precision medicine strategies differ based on the genetic underpinnings of vascular conditions.

Purpose of the Study:

  • To explore precision medicine for vascular diseases.
  • To differentiate approaches for atherosclerosis versus Mendelian vascular diseases.

Main Methods:

  • Review of genetic basis for atherosclerosis.
  • Review of genetic basis for Mendelian vascular diseases.
  • Comparison of precision medicine strategies for both disease types.

Main Results:

  • Atherosclerosis involves numerous genetic factors (polymorphisms).
  • Mendelian vascular diseases are caused by single gene defects.
  • Distinct precision medicine strategies are required for each disease category.

Conclusions:

  • Precision medicine requires tailored genetic approaches for vascular diseases.
  • Understanding genetic complexity is key for effective vascular disease treatment.
  • Future research should focus on specific genetic targets for atherosclerosis and Mendelian vascular diseases.

Keywords:
cardiovasculargeneticspolygenic risk scoreprecision medicinevascular

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