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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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Candidemia and Invasive Candidiasis.

Todd P McCarty1, Cameron M White2, Peter G Pappas2

  • 1University of Alabama at Birmingham, Birmingham VA Medical Center, 1900 University Boulevard, THT 229, Birmingham, AL 35294, USA.

Infectious Disease Clinics of North America
|May 21, 2021
PubMed
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Invasive candidiasis (IC) is a serious fungal infection. Early detection and treatment using clinical factors and advanced diagnostics are crucial for high-risk patients to improve outcomes.

Keywords:
AntifungalsBloodstream infectionCandidaFungal infectionInvasive candidiasis

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Invasive candidiasis (IC) encompasses diverse syndromes caused by Candida species.
  • Candidemia is a common manifestation, but IC can affect any organ system, including visceral organs, vasculature, bones, joints, eyes, and the central nervous system.

Purpose of the Study:

  • To highlight the importance of targeted prevention and empirical therapy for invasive candidiasis.
  • To emphasize the need for an updated approach combining clinical risk factors and non-culture-based diagnostics.

Main Methods:

  • Review of current understanding of invasive candidiasis syndromes.
  • Analysis of diagnostic and therapeutic strategies for high-risk patients.

Main Results:

  • Invasive candidiasis presents with varied clinical syndromes beyond candidemia.
  • Effective management relies on early identification of at-risk individuals.

Conclusions:

  • A combined approach using clinical risk assessment and non-culture-based diagnostics is recommended for managing invasive candidiasis.
  • Timely interventions are critical for improving patient prognosis in invasive candidiasis.