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Updated: Nov 5, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
12.4K
Emerging functions of circular RNA in aging
Eunah Kim1, Yoon Ki Kim2, Seung-Jae V Lee1
1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, South Korea.
Trends in Genetics : TIG
|May 21, 2021
Summary
Circular RNAs (circRNAs) levels change with age, impacting animal aging and longevity. These molecules show potential as aging biomarkers and in understanding age-related diseases.
Area of Science:
- Molecular Biology
- Gerontology
- Genetics
Background:
- Circular RNAs (circRNAs) are prevalent eukaryotic transcripts with age-dependent expression changes across species.
- circRNAs are implicated in cellular senescence and the development of age-related diseases.
Purpose of the Study:
- To review the functional roles of circRNAs in animal aging and longevity.
- To explore the characteristics of aging-associated circRNAs, including their potential as biomarkers.
Main Methods:
- Literature review of studies on circRNA expression and function in aging.
- Analysis of research on differential circRNA expression in senescence and aging-associated diseases.
Main Results:
- circRNAs exhibit altered expression patterns with age in various tissues and species.
- Aging-associated circRNAs possess tissue specificity, conserved characteristics, and distinct physiological roles.
- circRNAs are being investigated for their potential as biomarkers for aging and related conditions.
Conclusions:
- circRNAs play significant roles in the aging process and longevity.
- Understanding circRNA mechanisms offers insights into aging and age-related pathologies.
- Further research into circRNAs is crucial for advancing gerontology and developing novel therapeutic strategies.
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