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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Tricolor Transgenic Murine Model for Studying Growth Plate Injury
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Growth Modulation by Stimulating the Growth Plate: A Pilot Study.

Kathleen D Rickert1, Paolo Arrigoni2, Camille R Guzel3

  • 1Department of Orthopaedics, Duke University Medical Center, Durham, NC, USA; Department of Orthopedics, Rady Children's Hospital, San Diego, California, USA.

Ultrasound in Medicine & Biology
|May 21, 2021
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Summary

Low-intensity pulsed ultrasound (LIPUS) and recombinant growth hormone (rGH) injections effectively stimulated long bone growth in rabbits. These methods promoted microscopic bone growth without causing adverse effects, indicating potential therapeutic applications.

Keywords:
Bone growthGrowth plate stimulationLIPUSLimb lengthNoninvasivePhysis

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Area of Science:

  • Orthopedics and Regenerative Medicine
  • Biomedical Engineering
  • Skeletal Biology

Background:

  • Stimulating local bone growth is crucial for treating skeletal abnormalities and injuries.
  • Existing methods for bone growth stimulation have limitations, necessitating exploration of novel approaches.
  • Low-intensity pulsed ultrasound (LIPUS) and recombinant growth hormone (rGH) are potential candidates for enhancing bone formation.

Purpose of the Study:

  • To evaluate the efficacy of low-intensity pulsed ultrasound (LIPUS) and direct injection of recombinant growth hormone (rGH) in stimulating local long bone growth.
  • To assess the safety and potential adverse effects of LIPUS and rGH on the distal femoral physis in an animal model.

Main Methods:

  • A randomized controlled animal trial was conducted on immature rabbits.
  • Interventions included epiphyseal rGH periosteal injection, transdermal LIPUS, saline injection, or no treatment.
  • New bone deposition was tracked using calcein labeling, with microscopic growth measurements performed by blinded observers.

Main Results:

  • Both LIPUS and rGH treatments resulted in statistically significant increases in microscopic bone growth compared to control legs (35% and 41% increase, respectively; p < 0.05).
  • No significant differences in growth were observed among the control groups (p > 0.05).
  • No evidence of physeal bar formation was detected, suggesting a lack of short-term adverse effects.

Conclusions:

  • Direct injection of rGH and transdermal LIPUS application demonstrate a positive effect on microscopic long bone growth in rabbits.
  • These interventions appear to promote bone growth locally without inducing short-term adverse sequelae, such as physeal bar formation.
  • LIPUS and rGH show promise as therapeutic modalities for enhancing local bone growth in immature skeletal systems.