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Updated: Nov 5, 2025

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Distinguishing Primary Lateral Sclerosis from Parkinsonian Syndromes with the Help of Advanced Imaging
Pegah Masrori1,2,3, Donatienne Van Weehaeghe4,5, Koen Van Laere4,5
1Neuromuscular Reference Centre, Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
Abstract:
We describe a unique case of a patient presenting with unilateral mild paresis, slowing of the upper limb, and parkinsonism, who underwent a full imaging work-up including MRI, 123I-FP-CIT PET, 18F-FE-PE2I PET, and 18F-FDG PET. This case demonstrates that imaging may aid substantially in the diagnostic work-up of complex neurologic disorders.

