Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

3.7K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
3.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

3.0K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.0K
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

11.8K
Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action...
11.8K
Generation of Action Potential in Skeletal Muscles01:24

Generation of Action Potential in Skeletal Muscles

7.1K
Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...
7.1K
Action Potentials01:41

Action Potentials

138.3K
Overview
138.3K
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

8.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microvascular Decompression for Glossopharyngeal Neuralgia and Hemi-Laryngopharyngeal Spasm Syndrome.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same author

Medial forebrain bundle stimulation after failed subcallosal cingulate deep brain stimulation for treatment-resistant depression: Efficacy of a dual deep brain stimulation system for depression.

Brain stimulation·2023
Same author

Response to: Some historical remarks on ipsilateral hemiparesis and the absence of decussation of the pyramidal tracts.

Acta neurochirurgica·2021
Same author

Uncrossed corticospinal tracts presenting as transient tumor-related symptomatology.

Acta neurochirurgica·2021
Same author

Phenomenology of neurophysiologic changes during surgical treatment of carotid stenosis using signal analysis.

Clinical neurophysiology practice·2018
Same author

Canada Health Act: defend or reform.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2017

Related Experiment Video

Updated: Nov 5, 2025

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

27.2K

Intermuscular Coherence in the Presence of Electrical Stimulation.

Jonathan A Norton1

  • 1Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada.

Frontiers in Systems Neuroscience
|May 21, 2021
PubMed
Summary

Electrical stimulation applied at specific frequencies can alter neural oscillations. This study shows the nervous system can switch oscillatory frequencies, even when influenced by external stimulation, indicating adaptable neural processing.

Keywords:
coherenceelectrical stimulationmuscleoscillationsensory feedback

More Related Videos

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:14

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

216
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.3K

Related Experiment Videos

Last Updated: Nov 5, 2025

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

27.2K
Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:14

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

216
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.3K

Area of Science:

  • Neuroscience
  • Human Motor Control
  • Biomedical Engineering

Background:

  • The nervous system utilizes neural oscillations for efficient information processing.
  • Inter-muscular coherence in the 15-35 Hz range is associated with common cortical drive to muscles.
  • This frequency band overlaps with therapeutic electrical stimulation for movement restoration.

Purpose of the Study:

  • To investigate if voluntary effort can be discerned when electrical stimulation is applied at the peak frequency of inter-muscular coherence spectra.
  • To determine the effects of supra-threshold electrical stimulation on neural oscillatory patterns.

Main Methods:

  • Healthy human subjects underwent electrical stimulation of arm and leg muscles.
  • Electromyography (EMG) activity was recorded from pairs of muscles, including stimulated ones.
  • Offline coherence analysis was performed on the recorded EMG data.

Main Results:

  • When stimulation exceeded motor threshold and was applied at the peak coherence frequency, a new spectral peak emerged.
  • This novel oscillatory frequency was not observed at lower stimulation levels or frequencies.
  • The findings suggest the nervous system can adapt its oscillatory output in response to external input.

Conclusions:

  • The nervous system demonstrates plasticity by potentially switching oscillatory frequencies to adapt to environmental factors, such as noise or stimulation.
  • Electrical stimulation at specific frequencies can induce new patterns of neural oscillation.
  • Understanding these interactions is crucial for optimizing neurorehabilitation strategies.