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Correlation between serum urea nitrogen, cystatin C, homocysteine, and chronic heart failure
Zongqin Yao1, Guangfeng Li2, Guangcai Li3
1Department of Cardiology, Linyi Central Hospital Linyi, Shandong Province, China.
Insights
Elevated uric acid (UA), cystatin C (Cys-C), and homocysteine (Hcy) levels are linked to chronic heart failure (CHF). These markers show potential for early CHF screening and clinical evaluation.
Area of Science:
- Biochemistry
- Cardiology
- Clinical Diagnostics
Background:
- Chronic heart failure (CHF) is a complex clinical syndrome.
- Biomarkers for early detection and risk stratification in CHF are crucial.
Purpose of the Study:
- To investigate the correlation between serum uric acid (UA), cystatin C (Cys-C), and homocysteine (Hcy) levels and chronic heart failure (CHF).
- To assess the utility of these biomarkers in evaluating CHF severity and outcomes.
Main Methods:
- A case-control study involving 45 CHF patients and 45 healthy controls.
- Measurement of serum UA, Cys-C, and Hcy levels in all participants.
- Correlation analysis with clinical parameters including cardiac function classification, major adverse cardiovascular events (MACE), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), and New York Heart Association (NYHA) grade.
Main Results:
- CHF patients exhibited significantly higher serum UA, Cys-C, and Hcy levels compared to controls (P<0.05).
- These biomarker levels increased with worsening cardiac function classification and were higher in patients with MACE.
- Positive correlations were observed between UA, Cys-C, Hcy and LVEDD and NYHA grade, and negative correlations with LVEF (P<0.05).
- Combined diagnostic sensitivity for CHF was higher than individual markers, though specificity was lower.
Conclusions:
- Serum UA, Cys-C, and Hcy levels are elevated in CHF patients.
- These biomarkers may serve as valuable reference indexes for the clinical screening of early CHF.
- They offer potential for clinical evaluation and risk stratification in patients with chronic heart failure.
Objective:
To explore the correlation between uric acid (UA), cystatin C (Cys-C), homocysteine (Hcy), and chronic heart failure (CHF).
Methods:
45 patients with CHF were selected as the research group; 45 healthy people were selected as the control group. The levels of serum UA, Cys-C and Hcy were detected.
Results:
The in The research group had much higher levels of serum UA, Cys-C and Hcy than the control group (all P<0.05). The levels of above indexes also increased with an increase in cardiac function classification. Patients with major adverse cardiovascular events (MACE) had much higher levels of serum UA, Cys-C, and Hcy than those without MACE in the research group (all P<0.05). In addition, the levels of these above indexes in the research group were all positively correlated with the left ventricular end diastolic diameter (LVEDD) (all P<0.05), and all negatively correlated with the f left ventricular ejection fraction (LVEF) (P<0.05). What is more, the levels of these above indexes in the research group were all positively correlated with New York Heart Association (NYHA) grade (all P<0.05). The diagnostic sensitivity of serum UA level, Cys-C level, and Hcy level in joint diagnosis of CHF patients was higher than that of any single index diagnosis (P<0.05), and the specificity of combined diagnosis was lower than that of single index diagnosis (P<0.05).
Conclusion:
The levels of serum UA, Cys-C, and Hcy in CHF patients may be used as reference indexes for clinical screening of early CHF patients and could provide a certain reference for clinical evaluation.
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