Related Experiment Video
Updated: Nov 5, 2025
Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
Published on: March 1, 2024
Clinical significance of MDRO screening and infection risk factor analysis in the ICU
Yan Zhou1,2, Fan Yu1, Ying Yu1
1Department of Laboratory Medicine, West China Second University Hospital, Sichuan University Chengdu 610041, Sichuan Province, China.
Objective:
This study aimed to investigate the clinical significance of multi-drug resistant organism (MDRO) screening and infection risk factor analysis in the intensive care unit (ICU).
Method:
A total of 210 patients treated in the ICU of our hospital were enrolled as the study subjects, and were divided into the MDRO group (n=100 cases) and the non-MDRO group (n=110) according to the presence or absence of MDRO infection after examination of the pharyngeal swabs. The pathogens of MDRO infection and drug resistance were analyzed. The single-factor as well as multifactor logistic regression analysis of MDRO infections were carried out and the 30-d mortality rate, hospitalization time and treatment costs were compared between the two groups.
Results:
A total of 158 MDRO strains were detected in 100 patients with MDRO infection, of which G-84 accounted for 53.16% and G+ 74 accounted for 46.84%. The resistance analysis revealed that G-MDRO was sensitive to imipenem and G+ MDRO was sensitive to vancomycin, and no vancomycin-resistant MDROs were found. The logistic regression model and multifactorial analysis showed that mechanical ventilation, arterial and venous intubation, implementation of fiberoptic bronchoscopy, concurrent chronic lung disease and chronic cardiovascular disease were independent risk factors for the development of MDRO infection (P<0.05). The length of hospital stay, cost of treatment, and 30-d mortality rate in the MDRO group were significantly higher than those in the non-MDRO group (P<0.05).
Conclusion:
ICU mechanical ventilation, arterial and intravenous intubation, fiberoptic bronchoscopy, concurrent chronic lung disease and chronic cardiovascular disease are the independent risk factors for MDRO infection.
Insights
Multi-drug resistant organism (MDRO) infections in the intensive care unit (ICU) are linked to longer hospital stays and higher mortality. Key risk factors include mechanical ventilation and invasive procedures.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Microbiology
Background:
- Multi-drug resistant organisms (MDROs) pose a significant threat in intensive care units (ICUs).
- Understanding risk factors for MDRO infections is crucial for effective patient management.
Purpose of the Study:
- To determine the clinical significance of MDRO screening in the ICU.
- To identify independent risk factors associated with MDRO infections.
Main Methods:
- A cohort of 210 ICU patients was divided into MDRO (n=100) and non-MDRO (n=110) groups.
- Pathogen analysis, drug resistance profiling, and logistic regression were employed.
- Clinical outcomes including mortality, hospitalization time, and costs were compared.
Main Results:
- 158 MDRO strains were identified; Gram-negative and Gram-positive organisms predominated.
- Mechanical ventilation, intubation, bronchoscopy, and chronic comorbidities were significant risk factors for MDRO infection (P<0.05).
- The MDRO group experienced significantly longer hospital stays, higher treatment costs, and increased 30-day mortality (P<0.05).
Conclusions:
- Mechanical ventilation, invasive procedures (intubation, bronchoscopy), and chronic diseases are independent risk factors for ICU MDRO infections.
- MDRO infections significantly increase patient morbidity and healthcare resource utilization.
More Related Videos
11:17Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
15:28A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
Published on: January 17, 2014
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
01:25Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...