Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.5K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.5K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

76
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
76
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

105
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
105
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

1.4K
The pathophysiology of pneumonia involves the following steps:
1.4K
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

105
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
105
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

70
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
70

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinico-Radiological Profile, Management Strategies, and Survival Outcomes in Medulloblastoma: A Retrospective Study From a Tertiary Care Center.

Cureus·2026
Same author

Maternal ophthalmic artery Doppler peak ratio in normal pregnancy and pre-eclampsia and its association with pregnancy outcomes.

Journal of obstetrics and gynaecology of India·2026
Same author

Predictors of response to botulinum toxin treatment in patients with primary hemifacial spasm: A prospective cohort study.

Parkinsonism & related disorders·2026
Same author

From skull to face: MRI vs. CBCT-based soft tissue depths in forensic 3D craniofacial reconstruction.

Journal of forensic and legal medicine·2026
Same author

Building a national repository of dural-based lesions: clinical, pathological, and demographic insights from the Indian population.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same author

Comparison of Suprascapular Nerve Block With Glenohumeral Joint Dilatation for the Treatment of Adhesive Capsulitis of the Shoulder Joint.

Cureus·2025

Related Experiment Video

Updated: Nov 5, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K

Severe COVID-19: A distinct entity.

Ravindra Kumar Garg1, Gyan Prakash Singh2, Rajiv Garg3

  • 1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Journal of Family Medicine and Primary Care
|May 21, 2021
PubMed
Summary
This summary is machine-generated.

Severe coronavirus disease-2019 (COVID-19) can rapidly progress to critical illness, particularly in older men with comorbidities. Current treatments lack efficacy, highlighting the need for supportive care and mechanical ventilation for severe COVID-19 patients.

Keywords:
CoagulopathySARS-COV-2cytokine stormhypoxemialymphopeniamechanical ventilation

More Related Videos

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

Related Experiment Videos

Last Updated: Nov 5, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Pulmonology

Background:

  • Severe coronavirus disease-2019 (COVID-19) is a distinct clinical entity.
  • Approximately 15% of COVID-19 patients develop severe disease, and 5% become critically ill.
  • Risk factors include male sex, age over 65, and comorbidities.

Purpose of the Study:

  • To describe the characteristics and outcomes of severe and critical COVID-19.
  • To identify key pathophysiological mechanisms in severe COVID-19.
  • To outline management strategies for severe and critical COVID-19.

Main Methods:

  • Observational study based on Chinese experience.
  • Analysis of clinical data from severe and critical COVID-19 patients.
  • Review of existing literature on COVID-19 pathophysiology and treatment.

Main Results:

  • Cytokine storm leads to lung damage and multiorgan failure.
  • Coagulopathy and thromboembolism are common in critical illness.
  • Lymphopenia is associated with severe disease.
  • No antiviral or immunomodulator has proven efficacy.
  • Hypoxemia requires supplemental oxygen; ARDS, encephalopathy, and organ failure necessitate mechanical ventilation.

Conclusions:

  • Severe COVID-19 has a poor prognosis in many patients.
  • Management focuses on supportive care, oxygen therapy, and mechanical ventilation.
  • Healthcare workers face significant risk of SARS-CoV-2 infection in intensive care units.