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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Cadherins in Tissue Organization01:19

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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WNT5B in Physiology and Disease.

Sarocha Suthon1, Rachel S Perkins1, Vitezslav Bryja2,3

  • 1Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, United States.

Frontiers in Cell and Developmental Biology
|May 21, 2021
PubMed
Summary

WNT5B protein plays unique roles in cell functions and development, distinct from its relative WNT5A. Aberrant WNT5B signaling contributes to various diseases, including cancer and metabolic disorders.

Keywords:
WNT signalingWNT5AWNT5Bcancerdevelopment

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Area of Science:

  • Cell biology
  • Developmental biology
  • Molecular signaling

Background:

  • WNT5B is a WNT family protein, closely related to WNT5A.
  • It signals via the non-canonical β-catenin-independent pathway.
  • WNT5B often antagonizes canonical WNT signaling.

Purpose of the Study:

  • To elucidate the distinct effects and mechanisms of WNT5B compared to WNT5A.
  • To investigate WNT5B's roles in various tissues and developmental processes.
  • To highlight the link between aberrant WNT5B signaling and disease.

Main Methods:

  • Comparative analysis of WNT5B and WNT5A functions.
  • Investigation of WNT5B signaling pathways.
  • Review of WNT5B's involvement in physiological and pathological processes.

Main Results:

  • WNT5B exhibits unique expression patterns and functions compared to WNT5A.
  • Distinct roles of WNT5B were identified in development, bone, adipose, cardiac, nervous, mammary, lung, and hematopoietic systems.
  • Aberrant non-canonical WNT5B signaling is implicated in diseases like osteoarthritis, obesity, and cancer.

Conclusions:

  • WNT5B possesses unique biological activities distinct from WNT5A.
  • Understanding WNT5B's specific mechanisms is crucial for its role in development and disease.
  • Targeting WNT5B signaling may offer therapeutic strategies for associated diseases.