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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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7
Recent Advances in Bronchopulmonary Dysplasia
Vivek V Shukla1, Namasivayam Ambalavanan2,3
1Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Indian Journal of Pediatrics
|May 21, 2021
Summary
Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants. This review synthesizes evidence on BPD prevention and management, crucial for improving infant outcomes.
Area of Science:
- Neonatology
- Pediatric Pulmonology
- Perinatal Medicine
Background:
- Bronchopulmonary dysplasia (BPD) is a significant cause of chronic lung disease in preterm infants requiring respiratory support.
- Its incidence remains stable or increasing due to improved survival rates of extremely preterm infants.
- BPD presents a multifactorial pathogenesis and variable clinical phenotypes, leading to substantial mortality and morbidity.
Purpose of the Study:
- To provide a clinically relevant overview of current evidence regarding the prevention of BPD.
- To summarize effective management strategies for preterm infants diagnosed with BPD.
- To offer a synopsis of research advancements in understanding BPD pathogenesis.
Main Methods:
- Review of existing scientific literature on BPD.
- Synthesis of basic science, translational, and clinical research findings.
- Analysis of evidence pertaining to BPD prevention and treatment protocols.
Main Results:
- Despite advances in neonatal care and understanding, BPD remains challenging to prevent and manage.
- The multifactorial nature of BPD necessitates a comprehensive approach to care.
- Improved survival of extremely preterm infants contributes to stable or increased BPD incidence.
Conclusions:
- Effective prevention and management strategies for BPD are critical for improving long-term outcomes in preterm infants.
- Continued research is essential to address the complexities of BPD pathophysiology.
- A clinically useful synopsis of evidence is provided to guide healthcare professionals.
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