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Updated: Nov 4, 2025

Translating Ribosome Affinity Purification TRAP to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
Published on: May 14, 2020
TRAPP structures reveal the big picture
1Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA.
Abstract:
Two papers in this issue provide new structural insights into the "TRAnsport Protein Particle" (TRAPP) complexes, which play crucial roles in Golgi function. Both papers focus on TRAPPIII, which activates the Rab protein Ypt1 in yeast or the homologous Rab1 in metazoans. The structures illuminate how TRAPPIII specifically recognizes its Rab protein substrate. Joiner et al (2021) also describe a membrane-anchoring mechanism for yeast TRAPPIII, while Galindo et al (2021) characterize the large subunits that define metazoan TRAPPIII.
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