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Related Experiment Videos

Carcinogenesis by nitroso-2-hydroxyethylurea in splenectomized hamsters.

W Lijinsky1, R M Kovatch, B J Thomas

  • 1NCI-Frederick Cancer Research Facility, Frederick, MD 21701.

Cancer Letters
|August 15, 1988
PubMed
Summary

Nitroso-2-hydroxyethylurea (NHEU) causes spleen hemangiosarcomas in hamsters. Removing the spleen prevented liver tumors, confirming they were metastases, not primary growths.

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Area of Science:

  • Oncology
  • Carcinogenesis
  • Veterinary Pathology

Background:

  • Nitrosoalkylureas are known carcinogens.
  • Hemangiosarcomas are common spleen tumors in Syrian hamsters.
  • Metastasis of spleen tumors to the liver is frequently observed.

Purpose of the Study:

  • To determine if liver hemangiosarcomas induced by nitroso-2-hydroxyethylurea (NHEU) are true metastases from the spleen.
  • To evaluate the effect of splenectomy on NHEU-induced carcinogenesis.
  • To assess the specificity of NHEU's carcinogenic activity.

Main Methods:

  • Surgically splenectomized female Syrian hamsters were treated with NHEU weekly for 22 weeks.
  • A control group of unsplenectomized hamsters received identical NHEU treatment.

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  • Survival times and tumor development in both groups were monitored.

    • Main Results:

    • Splenectomized hamsters survived significantly longer (median 45 weeks) than unsplenectomized hamsters (median 24 weeks).
    • No hemangiosarcomas of the liver were observed in the splenectomized group.
    • NHEU did not induce a significant increase in other tumor types.

    Conclusions:

    • The study confirms that liver hemangiosarcomas observed in NHEU-treated hamsters are indeed metastases from the spleen.
    • Splenectomy significantly extends survival in hamsters treated with NHEU.
    • NHEU exhibits specific carcinogenic activity primarily targeting the spleen in this model.