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Hasubanan alkaloids with anti-inflammatory activity from Stephania longa
Hui Liu1,2, Wan-Qin Liao1,2, Rong-Xiao Lin3
1School of Medicine, Foshan University, Foshan, P. R. China.
Abstract:
Two new hasubanan alkaloids, stephalonester A (1) and stephalonester B (2), together with four known compounds, stephalonine E (3), longanone (4), cephatonine (5), and prostephabyssine (6) were isolated from the whole plant of Stephania longa. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR, ECD calculations, as well as by comparison with literature values. All compounds were evaluated for their anti-inflammatory activity in vitro. Compounds 4, 5, and 6 exhibited significantly inhibitory effects on TNF-α and IL-6 production with IC50 values range from 6.54 to 30.44 µM.
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