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Relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China

Meng Li1,2, Jun Xu3, Qin Wan4

  • 1Department of Pneumology, Bijie Hospital of Traditional Chinese Medicine, Guizhou, China.

The Journal of International Medical Research
|May 21, 2021
PubMed

Insights

Vitamin D3 deficiency is linked to a higher risk of anemia in Chinese patients with chronic kidney disease (CKD). Lower vitamin D levels correlate with increased anemia prevalence across CKD stages.

Area of Science:

  • Nephrology
  • Endocrinology
  • Hematology

Background:

  • Anemia is a common complication in patients with chronic kidney disease (CKD).
  • Vitamin D deficiency is prevalent among CKD patients and may influence hematopoiesis.

Purpose of the Study:

  • To investigate the association between serum vitamin D3 levels and anemia in Chinese CKD patients.
  • To inform potential vitamin D treatment strategies for anemia in CKD.

Main Methods:

  • 225 CKD patients were categorized into severe deficiency, deficiency, and sufficiency groups based on serum 25-hydroxyvitamin D3.
  • Anemia prevalence was assessed across groups.
  • Logistic regression analyzed factors associated with anemia in CKD.

Main Results:

  • Anemia prevalence was 79.5% in severe deficiency, 63.5% in deficiency, and 48.0% in sufficiency groups.
  • Anemia prevalence increased with the severity of vitamin D3 deficiency.
  • Anemia prevalence rose significantly with CKD stage, reaching 94.6% in stage 5.

Conclusions:

  • Vitamin D3 deficiency is associated with an increased risk of anemia in patients with chronic kidney disease.
  • Findings suggest a potential role for vitamin D supplementation in managing anemia in CKD.
Abstract

Keywords:
Chronic kidney diseaseanemiaestimated glomerular filtration ratehemoglobinparathyroid hormonevitamin D3 deficiency

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