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Interdisciplinary Approach to Thrombosis Management in COVID-19 at a Large Academic Center

Manila Gaddh1, Cheryl L Maier2

  • 1Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.

JCO Oncology Practice
|May 21, 2021
PubMed

Insights

This study addresses the heightened risk of blood clots in COVID-19 patients. It presents a practical, tiered anticoagulation algorithm to guide clinicians in managing COVID-19-associated coagulopathy.

Area of Science:

  • Medicine
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19 is increasingly associated with coagulopathy and thrombosis.
  • Effective prevention and treatment strategies for thrombosis in COVID-19 patients are uncertain.
  • There is an urgent need for clinical guidance during the pandemic.

Purpose of the Study:

  • To provide practical guidance for managing COVID-19-associated coagulopathy.
  • To develop a clinical algorithm for anticoagulation in COVID-19 patients.
  • To offer a pathway for complex or refractory cases.

Main Methods:

  • Convened an interdisciplinary expert group (25 specialists in thrombosis).
  • Reviewed available literature on COVID-19 and coagulopathy.
  • Brainstormed and developed management strategies and a tiered anticoagulation algorithm.

Main Results:

  • A 3-tiered anticoagulation algorithm for COVID-19 patients was created.
  • A pathway for multidisciplinary review of difficult cases was established.
  • The algorithm aims to assist frontline providers in patient management.

Conclusions:

  • Clinical algorithms can aid frontline providers in managing COVID-19 coagulopathy.
  • This guidance is particularly valuable given the novelty of the disease and limited data.
  • The proposed algorithm offers practical support for thrombosis management in COVID-19.

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