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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Nov 4, 2025

Facial Transplants in Xenopus laevis Embryos
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Facial Transplantation: Principles and Evolving Concepts.

Rami S Kantar1, Allyson R Alfonso1, Gustave K Diep1

  • 1From the Hansjörg Wyss Department of Plastic Surgery and the Transplant Institute, New York University Langone Health.

Plastic and Reconstructive Surgery
|May 21, 2021
PubMed
Summary

Facial transplantation has advanced significantly, offering a reconstructive option for severe facial disfigurement. This review covers key aspects from indications to outcomes, highlighting its role in improving patient function and aesthetics.

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Area of Science:

  • Plastic Surgery
  • Transplantation Medicine
  • Reconstructive Surgery

Background:

  • Facial transplantation has evolved over two decades.
  • Over 40 facial allografts have been reported globally.
  • It represents a complex reconstructive option for extensive facial disfigurement.

Observation:

  • Key considerations include indications, contraindications, and donor/recipient selection.
  • Logistical, immunologic, and cost factors are critical.
  • Emerging technologies are influencing the procedure.

Findings:

  • Surgical approaches and technical nuances are detailed.
  • Aesthetic, functional, and psychosocial outcomes have been reported.
  • Facial transplantation is a high-level reconstructive solution when autologous methods fail.

Implications:

  • Facial transplantation offers significant functional and aesthetic improvements for select patients.
  • Understanding the complexities is crucial for successful implementation.
  • Continued advancements promise better outcomes in reconstructive surgery.