Related Experiment Video

Updated: Nov 4, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

35.0K

Immune cells-A curse and a blessing!

Valbona Mirakaj1

  • 1Department of Anesthesiology and Intensive Care Medicine, Molecular Intensive Care Medicine, University Hospital Eberhard Karls University, Tübingen, Germany.

The Journal of Experimental Medicine
|May 21, 2021
PubMed

Insights

Innate immune cells significantly influence cardiovascular disease progression. Recent studies highlight their critical role in both the development and regulation of these conditions.

Area of Science:

  • Immunology
  • Cardiovascular Science

Background:

  • Innate immune cells play a complex role in cardiovascular disease (CVD).
  • Understanding their specific contributions is essential for therapeutic development.

Purpose of the Study:

  • To elucidate the impact of innate immunity on cardiovascular disease pathogenesis.
  • To provide insights into the regulatory mechanisms of innate immune cells in CVD.

Main Methods:

  • Review of recent findings from Davis et al. and Li et al. in the Journal of Experimental Medicine.
  • Analysis of the interplay between innate immune responses and cardiovascular conditions.

Main Results:

  • Innate immune cells are integral to the development of cardiovascular disease.
  • These cells also play a regulatory role in the progression of CVD.

Conclusions:

  • Targeting innate immune pathways presents a potential therapeutic strategy for cardiovascular disease.
  • Further research is warranted to fully understand the multifaceted roles of innate immunity in CVD.

More Related Videos

T Cells Capture Bacteria by Transinfection from Dendritic Cells11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

12.1K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

3.7K

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
78.4K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
7.3K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
6.6K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
5.5K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
864