Related Experiment Video

Updated: Nov 4, 2025

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

209

Effects of circadian variation, lifestyle and environment on hematological parameters: A narrative review

Joffrey Feriel1, Draga Tchipeva1, François Depasse1

  • 1Diagnostica Stago, Asnieres Sur Seine, France.

International Journal of Laboratory Hematology
|May 21, 2021
PubMed

Insights

The complete blood count (CBC) is a common lab test. Lifestyle and environmental factors can significantly alter CBC results, impacting diagnosis.

Area of Science:

  • Clinical Pathology
  • Hematology
  • Laboratory Medicine

Background:

  • The complete blood count (CBC) is a cornerstone diagnostic tool in medicine.
  • Laboratory errors, particularly preanalytical and analytical, significantly impact CBC accuracy.
  • External factors like circadian rhythms and lifestyle choices also influence CBC results.

Purpose of the Study:

  • To comprehensively review the literature on factors affecting CBC results.
  • To identify clinically significant changes in CBC parameters due to various conditions.
  • To guide healthcare professionals in interpreting CBC results accurately.

Main Methods:

  • Systematic literature search on factors influencing CBC.
  • Analysis of studies investigating circadian variation, lifestyle, and environmental impacts.
  • Compilation of data on affected cell types, intensity, and duration of changes.

Main Results:

  • Circadian variation, sleep-wake cycle changes, exercise, diet, alcohol, tobacco, drugs, altitude, temperature, and air pollution all affect CBC parameters.
  • Specific cell types and the magnitude/duration of changes are detailed for each factor.
  • Understanding these influences is crucial for accurate interpretation.

Conclusions:

  • Non-pathological factors can induce clinically significant CBC variations.
  • Healthcare professionals must consider these influences before diagnosing hematological disorders.
  • This review provides a guide to avoid misinterpretation of CBC results.

Keywords:
circadian variationcomplete blood count (CBC)environmenthematological parameterslifestyle

More Related Videos

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.8K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.2K

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
180
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.3K
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.4K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
4.3K
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
350
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
5.7K