Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.8K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.8K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.1K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.5K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.5K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.1K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.1K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.1K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.1K
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.9K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of leukocyte-platelet-rich fibrin in periodontal surgery on clinical parameters and patient-related outcome measures: A randomized, controlled, clinical study.

Journal of periodontology·2026
Same author

Population Health Management in Chronic Obstructive Pulmonary Disease: An Official American Thoracic Society Workshop Report.

Annals of the American Thoracic Society·2026
Same author

AI-quantified Myosteatosis at CAC CT for Prediction of Atrial Fibrillation and Heart Failure: The Multi-Ethnic Study of Atherosclerosis.

Radiology. Cardiothoracic imaging·2026
Same author

Palatal donor site wound healing following mucogingival surgery using amnion-chorion membrane: A randomized controlled clinical trial.

Journal of periodontology·2026
Same author

Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets.

Nature immunology·2026
Same author

AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillation and Stroke.

Stroke·2026

Related Experiment Video

Updated: Nov 4, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.2K

Lung Cancer Risk among Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap.

Antonios Charokopos1,2, Sidney S Braman1, Stacey A Whittaker Brown1

  • 1Division of Pulmonary and Critical Care, and.

Annals of the American Thoracic Society
|May 21, 2021
PubMed
Summary

Patients with asthma-COPD overlap (ACO) have a lung cancer risk similar to those with chronic obstructive pulmonary disease (COPD). This study highlights COPD, with or without asthma history, as an independent lung cancer risk factor.

Keywords:
ACONLSTincidencelung cancersmoking

More Related Videos

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.0K
Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells
09:15

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells

Published on: May 11, 2020

6.2K

Related Experiment Videos

Last Updated: Nov 4, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.2K
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.0K
Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells
09:15

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells

Published on: May 11, 2020

6.2K

Area of Science:

  • Pulmonology
  • Oncology
  • Epidemiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a known lung cancer risk factor.
  • The association between asthma and lung cancer is not well-established.
  • The lung cancer risk in asthma-COPD overlap (ACO) remains unstudied.

Purpose of the Study:

  • To compare lung cancer risk in patients with ACO versus COPD and other airway obstruction conditions.
  • To investigate the independent risk of ACO for lung cancer.
  • To clarify the role of comorbid asthma in COPD patients regarding lung cancer risk.

Main Methods:

  • Analysis of 13,939 smokers from the National Lung Cancer Screening Trial with baseline spirometry.
  • Categorization of participants into five airway disease subgroups using spirometric indices and childhood asthma history.
  • Utilized Poisson regression to compare adjusted and unadjusted lung cancer risk across subgroups.

Main Results:

  • Lung cancer incidence rates per 1,000 person-years: ACO (13.2), COPD (11.7), asthmatic smokers (1.8), Global Initiative for Chronic Obstructive Lung Disease-Unclassified (7.7), and normal spirometry smokers (4.1).
  • ACO patients showed increased adjusted lung cancer risk compared to asthma patients (IRR, 4.5) and normal spirometry smokers (IRR, 2.3).
  • Adjusted lung cancer incidence was not significantly different between ACO and COPD patients (IRR, 1.2).

Conclusions:

  • Lung cancer risk in ACO patients is comparable to COPD patients and higher than in other smoker subgroups.
  • COPD, irrespective of a childhood asthma history, is confirmed as an independent risk factor for lung cancer.
  • These findings underscore the importance of considering airway obstruction severity and overlap conditions in lung cancer risk assessment.