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Related Concept Videos

Teeth01:15

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Missing and unerupted teeth in osteogenesis imperfecta.

Doaa Taqi1, Hanan Moussa2, Timothy Schwinghamer1

  • 1Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.

Bone
|May 21, 2021
PubMed
Summary
This summary is machine-generated.

Osteogenesis imperfecta (OI) patients frequently experience missing and unerupted teeth, particularly premolars. These dental issues are linked to specific genetic variants and OI types, with early bisphosphonate treatment increasing unerupted tooth risk in some cases.

Keywords:
AgenesisBisphosphonateMissing teethOsteogenesis imperfectaRare diseaseRetained teethTooth developmentTooth eruptionUnerupted

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Area of Science:

  • Oral Health
  • Genetics
  • Pediatric Dentistry

Background:

  • Osteogenesis imperfecta (OI) is a genetic disorder causing bone fragility and significant craniofacial and dental abnormalities.
  • Missing and unerupted teeth are common in OI patients, impacting oral health quality of life, but their causes are not fully understood.

Purpose of the Study:

  • To investigate the prevalence of missing and unerupted teeth in a cohort of Osteogenesis Imperfecta patients.
  • To identify factors influencing these dental anomalies, including OI type, genetic variant, tooth type, and bisphosphonate treatment onset.

Main Methods:

  • A cohort of 144 Osteogenesis Imperfecta patients was analyzed using intraoral photographs and panoramic radiographs.
  • Missing teeth were assessed in all patients; unerupted teeth were assessed in patients aged 15 and older.

Main Results:

  • OI patients averaged 2.4 missing and 0.8 unerupted teeth, with premolars and second molars most affected.
  • Missing teeth were more prevalent in OI types III and IV and associated with C-propeptide variants.
  • Unerupted teeth were more common with specific glycine variants, and early bisphosphonate treatment increased risk in OI types III and IV.

Conclusions:

  • The prevalence of missing and unerupted teeth in OI varies with collagen variants and OI type.
  • These findings underscore the critical role of collagen in tooth development and eruption processes.