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Updated: Nov 4, 2025

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
Published on: January 29, 2022
Controlling adhesion using AC electric fields across fluid films
Carla S Perez-Martinez1, Timothy S Groves2, Susan Perkin2
1London Centre for Nanotechnology, University College London, 17-19 Gordon Street, London WC1H 0AH, United Kingdom.
Abstract:
We demonstrate reversible and switchable actuation using AC electric fields to bring two surfaces separated by a thin film of ionic fluid in and out of adhesive contact. Using a surface force balance we apply electric fields normal to a crossed-cylinder contact and measure directly the adhesive force and surface separation with sub-molecular resolution. Taking advantage of the oscillatory structural force acting between the surfaces across the fluid, which we show to be unaffected by the AC field, we pick between the distinct (quantized) adhesive states through precise tuning of the field. This proof-of-concept indicates exquisite control of surface interactions using an external field.

